Zhengzhou Spirit: Prevention of Alternating Mania and Lethargy
Prevention of Alternating Mania and Lethargy
Due to the influence of disease factors such as rabies in children, mania and lethargy alternately occur, and the irritability is abnormal during attacks. The incubation period varies from 4 days to 19 years, and most of them are within 1 year. Factors that affect the incubation period are age (shorter in children), site of wound (early onset of head and face), nature of wound (shorter in deep bites), quantity, virulence and host defense mechanism of invading viruses, etc. So, what aspects should we prevent from the symptoms of alternating mania and lethargy?
Control and eliminate the source of infection: strengthen the management of dogs, wild dogs should be killed as much as possible, domestic dogs should be registered and vaccinated. Rabid dogs should be killed immediately, burned or buried deeply, and can be skinned. If it is not certain that they are rabies for a while, they should be isolated and observed for 10 days, and the brain tissue of the animals that were killed or died during the isolation period should be taken for pathogenic examination.
Vaccination: It is one of the important measures to prevent and control rabies.
- Xie immune serum: recommended by WHO, inject human rabies immunoglobulin (HRIG) at the same time as vaccination, the dose is 20U/kg (the dose of equine rabies immune globulin is 40U/kg), first do a skin test, and if it is negative, once a muscle Note or half of the dose is infiltrated around the wound, and the other half is injected intramuscularly. If the skin test is positive, desensitization treatment is required (0.05ml diluted 20 times, 0.05ml diluted 10 times, 0.1ml, 0.2ml, 0.5ml, undiluted antiserum were injected subcutaneously respectively, and each time was observed for 15 minutes) before injection.
At present, it is believed that the local presence of the virus is not the only factor leading to the difference in clinical manifestations. Humoral immunity and cell-mediated immunity have protective effects in the early stage, but when the virus enters the nerve cells and proliferates, the immune-mediated damage is also related to the disease. The death of immunosuppressed mice was delayed after inoculation with rabies virus, and the death was accelerated after passive infusion of immune serum or immune cells.
