Insomnia in Zhengzhou: What are the main pathogenic factors of alternating mania and lethargy

What are the main causative factors of alternating mania and lethargy

Due to the influence of disease factors such as rabies, mania and drowsiness alternately occur, and irritability is abnormal during attacks. Rabies is an acute infectious disease of the central nervous system caused by rabies virus. Because rabies patients have outstanding clinical manifestations of being afraid of drinking water, the disease was once called hydrophobia, but the affected animals do not have this characteristic. The main clinical manifestations are characteristic mania, fear, fear of wind and water, salivation and spasm of pharyngeal muscles, and eventually paralysis and life-threatening. What are the main causative factors for alternating mania and lethargy?

Rabies virus belongs to Rhabdoviridae, genus Lyssavirus. The shape of the virus is like a bullet, with a diameter of 75-80nm and a length of 175-200nm. The inner layer is a core shell, containing a 40nm core, and the outer layer is a dense envelope with many filamentous protrusions on the surface, and the distal end of the protrusions is mallet-shaped. The surface of the whole virus has a honeycomb hexagonal structure. The genome of the virus is negative-sense single-stranded RNA with a molecular weight of 4.6106. The viral genome is 11,932 nucleotides long, about 91% of which are involved in encoding five known structural proteins, namely glycoprotein (GP), envelope matrix protein (M2P), capsid matrix protein (M1P), Nucleoprotein (NP) and transcriptase protein (LP). Genomic RNA combines with 180 NP molecules to form ribonucleoprotein, which protects RNA from degradation and provides a suitable structural basis for genome replication and transcription.

At present, it is believed that the local presence of the virus is not the only factor leading to differences in clinical manifestations. Humoral immunity and cell-mediated immunity have protective effects in the early stage, but when the virus enters the nerve cells and proliferates, the immune-mediated damage is also related to the onset. The death of immunosuppressed mice was delayed after inoculation with rabies virus, and the death was accelerated after passive infusion of immune serum or immune cells. In human rabies, those whose lymphocytes are positive for the proliferation of rabies virus cells are mostly manic and die quickly. Those who have an autoimmune reaction to myelin basic protein (MBP) are also manic, and the disease progresses rapidly, and immune damage mediated by antibodies, complements, and cytotoxic T cells can be seen in brain tissue.