These 6 kinds of medicines should not be taken indiscriminately, some of them have been banned in foreign countries, and many people still use them as standing medicines

"Why can't you sell me medicine?"

Aunt Wang was very helpless. Her granddaughter had a fever, so she thought of rushing to the pharmacy to buy some anti-fever artifact "Analgin". But the clerk had to register his body information, and said that it could not be eaten by anyone under the age of 18.

Aunt Wang remembered that in the past, everyone in the family had a fever and took Analgin, which was cheap and effective. Why can't you buy it in pharmacies now? Aunt Wang thinks it must be cheap, so pharmacies don't want to sell it...

1. These 6 kinds of medicines have been "banned", do you still take them as standing medicines?

Some common backup drugs are easy to use and effective, but they may have been "banned" in some regions or countries, such as the following 6 drugs:

1. Compound Licorice Tablets

Compound licorice tablet is a compound preparation of Chinese and Western medicine for relieving cough . Its ingredients contain cocaine, also known as cocaine . In 2014, someone brought 16 bottles of compound licorice tablets to the United States. He was considered to be carrying contraband and was ordered not to enter the country for 5 years.

China's State Drug Administration issued a notice in July 2013, requiring pharmaceutical retail companies to set up special counters for compound licorice tablets, which are managed by special personnel and registered in special books .

In March 2020, the State Drug Administration revised the drug instructions of Compound Licorice Tablets, pointing out that Compound Licorice Tablets contain opioids , which will affect urine morphine detection during the medication period and within 3 to 4 days after drug withdrawal; if Dependence may occur with long-term use ; hypokalemia may result.

2. Ribavirin

Ribavirin, also known as ribavirin, is mainly used to treat severe lower respiratory tract infections caused by respiratory syncytial virus infection.

Ribavirin mainly includes injections, aerosols, nasal drops, oral preparations, etc. in China, and the clinical abuse is relatively serious. Injections are not approved in some European and American countries.

In 2006, the State Drug Administration had warned about the safety of ribavirin. A large number of studies have shown that ribavirin has obvious teratogenic and embryocidal toxic effects through animal experiments.

In addition, the main toxicity of ribavirin is hemolytic anemia, which may cause a decrease in red blood cells, hemoglobin, and white blood cells, and 10% of patients will also be accompanied by cardiopulmonary side effects.

3. Analgin

Analgin is an antipyretic and analgesic drug belonging to the pyrazolone class. It became a commonly used antipyretic and analgesic drug clinically in the 1920s, but it attracted widespread attention in the 1970s due to serious adverse reactions. The U.S. FDA officially banned Analgin in 1977.

In China, policies restricting the use of Analgin have been issued many times. In 1982, the former Ministry of Health eliminated the compound Analgin tablets. By 2020, various dosage forms of Analgin products will also stop production, sales and use.

Although there are still some Analgin drugs in circulation that have not yet canceled their production approval numbers, the State Food and Drug Administration revised the instructions for Analgin tablets in 2020, adding warnings to remind that it may cause blood system problems. Severe adverse reactions and possible severe allergic reactions should only be used when the condition is severe and there is no substitute for other drugs, and it is contraindicated for children under the age of 18.

4. Pidotimod

Pidotimod is a synthetic immune booster, once a best-selling drug in pediatrics, but there is still a lack of high-quality and reliable clinical research.

In China, in March 2018, the State Drug Administration revised the instructions of various preparations of pidotimod, and then issued a notice requiring manufacturers of pidotimod preparations to start clinical effectiveness trials as soon as possible, and to obtain approval within 3 years. Evaluation results.

5. Domperidone

Domperidone is a peripheral dopamine receptor blocker, which can directly act on the gastrointestinal wall, enhance gastric motility, inhibit vomiting, nausea, and prevent bile reflux. It is often used as a digestive aid for a long time in China.

The U.S. FDA has not approved any indications for domperidone, and it has been approved for marketing in many European countries.

In 2016, China's State Drug Administration revised the instructions of domperidone preparations, clarifying that some patients taking domperidone may increase the risk of severe ventricular arrhythmia or even sudden cardiac death , and prohibition of erythromycin, Combination of drugs such as ketoconazole oral preparations.

6. Phenolphthalein Tablets

Phenolphthalein tablet is a kind of irritating "laxative". Many people often use it to treat constipation or lose weight. It is cheap, and has a strong and fast effect on treating constipation. It is often used clinically to treat intractable constipation or to do colonoscopy Bowel cleansing before the test.

However, phenolphthalein tablets contain irritating ingredients. Long-term use will lead to drug accumulation, stimulate and damage the intestinal mucosa, and may cause melanosis of the colon in severe cases, increasing the chance of intestinal cancer.

On January 14, 2021, the State Drug Administration of China announced that it would stop the production, sale and use of phenolphthalein tablets and phenolphthalein buccal tablets in China , and cancel the registration certificate of the drug.

2. Taking medicine in a healthy and safe way, all of these steps are indispensable

There are also big questions about taking medicine. If you want to take medicine safely and healthily, you must read the instructions carefully and understand these 5 pieces of information:

First of all, when buying medicine, you must look for the OTC logo on the upper right corner of the medicine box. OTC medicines are non-prescription medicines, and they can be divided into Class A with red background, Class A and Class B with green background. Green has a higher safety factor .

Secondly, all regular medicines or health care medicines in China have the words "Guoyao Zhunzi" on the instructions. If the words "Guoshijianzi" or "Weishijianzi" are marked on the instructions, it means that they are only health food and not health medicines. . "Health Medicine and Health Character" has been abolished, do not take this kind of medicine.

In addition, look at the shelf life of the drug clearly. Once the drug expires or deteriorates, it will not only cause the drug to fail, but may also cause toxic reactions. Therefore, be careful not to take medicines that are close to the expiration date and medicines that have changed in appearance.

It also depends on the contraindicated group . "Use with caution" is a primary warning, and "Don't use" and "Forbidden" are more severe warnings. If you belong to a contraindicated group, the occurrence of adverse reactions may increase, so you must communicate with your doctor for confirmation.

Finally, take according to the dose and time. Taking medicine before meals generally refers to 15-30 minutes before meals, taking medicine after meals generally refers to 15-30 minutes after meals, and taking medicine on an empty stomach generally refers to 1-2 hours before meals.

3. Effervescent tablets, slow-release tablets, and chewable tablets have different correct postures for taking medicine

The dosage form of the drug is different, and the method of taking it is also different. For these special dosage forms below, pay attention to these separately.

For effervescent tablets , never put them directly into your mouth or take them with water. It is recommended to soak them in 100-150ml of warm water first, and drink them after the bubbles completely disappear.

Sustained-release tablets should usually be swallowed whole, and should not be chewed or broken. Please refer to the drug instructions for details.

Chewable tablets should be chewed fully in the mouth before swallowing or taken with a small amount of warm water.

Sublingual lozenges, which are usually ineffective if swallowed directly, should be held under the tongue for about five minutes, or until completely dissolved.

In short, no matter what medicine you take, you must read the instructions carefully, preferably take it under the guidance of a doctor, and never abuse drugs.

References:

[1] When will "Analgin Films" Be Eliminated? ". Chinese Pharmacy. 2022-05-15

[2] "These 6 drugs that have been banned are still used by many people", is it true? ". Center for Drug Evaluation. 2020-04-07

[3] "Comprehensive shutdown! This commonly used drug has cancer risk? Please throw away what you have at home... ". Popular Science China. 2021-01-21

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