Cephalosporin paired with wine, eat and go! What is the difference between drinking alcohol after taking cephalosporins and taking cephalosporins after alcohol?

The cephalosporin is paired with wine, and you can leave as soon as you say it. This sentence is familiar to many people, especially friends who drink alcohol.

There was a Mr. Liu in Jiangsu. He couldn't think about the breakup. After drinking 6 bottles of beer, he ate 2 boxes of cephalosporins. When the police arrived, Mr. Liu was pale, vomited foam, and was in a coma.

He was rushed to the hospital for emergency treatment and was out of danger in time. The doctor said that cephalosporins and alcohol should be used for a period of time, whether it is drinking before taking the medicine or drinking after taking the medicine, otherwise the disulfiram reaction will easily occur and cause life-threatening.

1. What is the difference between drinking alcohol after taking cephalosporins and drinking alcohol before taking cephalosporins?

In fact, the two situations lead to very different results.

· Drinking alcohol after taking cephalosporin

If you drink alcohol after taking cephalosporins, you should stop drinking immediately, pay attention to keeping warm, drink sugar water, promote urination, lie down and rest, etc. Light people can be relieved by these behaviors.

If you have serious symptoms such as paleness, sweating, vomiting, etc., call the emergency number in time. At the same time, induce vomiting, remove vomit secretions from the mouth and nose, and pay attention to turning the head sideways to avoid suffocation.

How long should you not drink alcohol after using cephalosporins?

There are four aspects to consider in this question, one is the strength of the drug to inhibit acetaldehyde dehydrogenase, the second is the half-life of drug elimination, the third is the recovery time after acetaldehyde dehydrogenase is inhibited, and the fourth is the physical condition of different patients.

Different medicines vary, and older adults take longer . In conclusion, it takes at least a week after cephalosporins to drink alcohol or come into contact with alcoholic foods or medicines, and two weeks apart to be considered safe.

· Eating cephalosporins after drinking alcohol

At this time, if a disulfiram-like reaction occurs, the mild cases will have facial or whole body skin flushing, dizziness, headache, palpitation, nausea and vomiting, etc., and the severe cases will feel chest tightness, dyspnea, shock, and even disturbance of consciousness, size Incontinence, etc., can be life-threatening.

After drinking alcohol, how long can you not take cephalosporins? Check to see if there are still ethanol and acetaldehyde left in the body.

According to the experimental results of a healthy volunteer study conducted in China, the pharmacokinetic parameters of ethanol in different individuals will also be quite different.

The peak time of ethanol is about 0.8~2.0 hours, and the elimination half-life time is 0.5~2.6 hours, which means that ethanol can be basically eliminated after 3~15.6 hours. Acetaldehyde, a metabolite of ethanol, takes longer to eliminate in the body. Therefore , after drinking alcohol, it is forbidden to use cephalosporins within one day, and cephalosporin antibiotics that cause disulfide reactions are avoided for 2 to 3 days.

2. In addition to cephalosporins, there are these drugs to avoid alcohol

The cephalosporins that cause disulfiram-like reactions include cefoxitin, cefoperazone, laoxetine, cefamandole, cefuroxime, ceftazidime, ceftriaxone, cefaclor, cefathiamidine, and the like.

Nowadays, many people know the common sense that alcohol cannot be used in combination with cephalosporins. In fact, in addition to cephalosporins, there are some drugs that cannot be used at the same time as alcohol.

Antipyretic and analgesic drugs: aspirin, paracetamol and other drugs have the effect of stimulating and damaging the gastric mucosa, and alcohol also has a harmful effect on the stomach. Therefore, the simultaneous use of the two may cause symptoms such as gastritis, gastric ulcer, and gastric bleeding. Shock may occur, posing a serious threat to life.

Some antihypertensive drugs: After taking antihypertensive drugs such as reserpine and captopril , if you drink wine, the tyramine in the wine cannot be degraded, which may cause life-threatening symptoms such as vasodilation, hypotension, and even shock.

Hypoglycemic drugs: Alcohol can stimulate insulin secretion, and patients with diabetes who drink alcohol during oral hypoglycemic drugs may cause hypoglycemia. It is mostly manifested as palpitation, fatigue, sweating, multilingualism and other symptoms, and it is not easy to distinguish it from the symptoms of drunkenness. In addition, metformin and alcohol may have a side effect that increases the risk of lactic acidosis .

Sedative and hypnotic drugs: such as phenobarbital, chloral hydrate, diazepam, chlordiazepoxide and other brain depressants, when used together with alcohol, under the action of ethanol, it will speed up the absorption and slow down its metabolism. The concentration will increase rapidly.

Alcohol will first excite and then inhibit the central nervous system of the brain, and these brain inhibitors can affect the normal activity of the central nervous system. Patients may experience coma, shock, respiratory failure, and even death. In addition, sleeping pills such as solazepam or Ambien can be dangerous when combined with alcohol and can cause severe drowsiness and dizziness.

Antidepressants: Both antidepressants and alcohol have a delaying effect on the central nervous system, affecting brain function and thinking. Using the two at the same time can make people sleepy, reduce human judgment, physical coordination and reaction time, and even worsen depression.

Monoamine oxidase inhibitors can interact with alcohol , so both should be avoided entirely.

3. Drinking a drop is also harmful, but the benefits of quitting drinking are obvious

Although the harm of drinking has been popularized many times, there are still many other voices that have emerged: "Drinking in moderation is good for cardiovascular health", "Drinking before going to bed helps sleep and health", "Drinking in moderation is fine, drinking too much is not good" .. .These are incorrect.

The Lancet makes it clear that drinking even a drop of alcohol is useless. But if you stop drinking, your health will beckon you.

The Royal Free Hospital in London, England, conducted an experiment on three groups of women, allowing them to stop drinking for a month , and control the changes before and after. The researchers divided the women into light, moderate, and heavy drinkers based on how much they drank.

The results of the three groups of women who stopped drinking showed that the light drinkers had a 14% reduction in liver stiffness and cytokine levels, respectively, and a 6 mm Hg drop in systolic blood pressure. Moderate drinkers had 9 mmHg lower systolic blood pressure, heavy drinkers had 40% and 15% lower systolic blood pressure and 10 mmHg lower systolic blood pressure, respectively. Some of these women lost weight, slept better, and became more emotionally stable.

Life and health are more important than everything else. In our daily life, we should pay attention to avoiding the combined use of drugs and alcohol, and at the same time, reduce alcohol consumption for the sake of health.

references:

[1] ""Cefs just drink, just leave"? Danger! Don't drink alcohol while taking these drugs...". Popular Science China. 2021-02-15

[2] "Emergency Reminder! In addition to cephalosporins, do not drink alcohol while taking these medicines! Hurry up and tell your family...". Popular Science China. 2021-04-06

[3] What happens after 1 month of quitting drinking? These amazing changes have taken place in them...". Health Times. 2018-08-09

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