Can improper diet cause hyperuricemia? Reminder: There are 5 other reasons why it occurs!

Relevant research surveys show that the prevalence of hyperuricemia in China is increasing year by year, and the total number of patients is close to 120 million , accounting for about 10% of the Chinese population. It has become the fourth highest after the three high diseases, and is one of the most common metabolic diseases in China.

　　It is precisely because of the large population base of patients with hyperuricemia that the incidence of gout in China is also increasing year by year.

　　Due to the emergence of many metabolic diseases, they are related to unhealthy eating habits . So, when you hear about hyperuricemia, the first thing that comes to your mind is unhealthy dietary choices.

　　In fact, in terms of uric acid, the onset of hyperuricemia may indeed be related to dietary factors , because it is the end-stage product of purine metabolism.

　　There are two main sources of purines. The first is the endogenous purines produced in the body . Second, exogenous purines , such as animal offal, red meat, seafood, beer , etc., are typical high-purine foods.

　　Long-term intake of large amounts of these foods will naturally increase the production of blood uric acid in the body, thus increasing the risk of hyperuricemia.

　　However, diet is not the only and absolute factor for hyperuricemia, its pathogenesis is also related to the following reasons:

1. Genetics

　　Clinically, nearly 60% of primary hyperuricemia is actually related to heredity. Of course, this does not mean that the disease is directly passed on to the next generation, but that there are susceptibility genes in the genes of the next generation .

At present, 28 susceptibility genes closely related to hyperuricemia　　have been found clinically . People with this gene have a higher prevalence than others;

　　2. Gender

　　A large number of studies have shown that the incidence of hyperuricemia is also related to gender. Compared with men, the incidence of hyperuricemia in young and middle-aged women is much lower. In postmenopausal women, the incidence is similar to that of men.

　　The reason for this is that uric acid metabolism is related to estrogen levels, and estrogen can increase the rate of uric acid metabolism and reduce blood uric acid levels. At the same time , estrogen can also inhibit the phagocytosis of urate crystals by white blood cells , thereby reducing the risk of gout attacks;

3. Age factor

　　The higher and lower blood uric acid levels are also affected by age. Relevant studies have pointed out that the concentration of uric acid in children is only 180-240 μmol/L.

　　However, after puberty, blood uric acid levels begin to increase rapidly . With the increase of age, the uric acid clearance rate will be lower, the uric acid excretion will gradually decrease , and the incidence of hyperuricemia will increase;

　　4. Metabolism

　　The vast majority of hyperuricemia and gout patients have different degrees of lipid metabolism disorders, and nearly 80% of hyperlipidemia patients have hyperuricemia at the same time .

　　The reason for this is related to similar eating habits. In addition, studies have found that people with type 2 diabetes are affected by higher insulin levels and are also prone to the disease;

5. Obesity factor

　　A large number of studies have shown that obesity is a risk factor for hyperuricemia and gout. The more the BMI index exceeds the standard, the greater the risk of hyperuricemia.

　　This is because obesity not only increases the amount of uric acid synthesis, but also reduces the ability of the kidneys to excrete uric acid , which in turn increases the possibility of excess uric acid.

　　In addition to the above reasons, high blood pressure, living environment (altitude, climate and temperature), emotions, some drugs, and other disease factors may all lead to excessive blood uric acid levels.

　　Therefore, everyone cannot blame the diet for the excessive uric acid level. After the diagnosis of hyperuricemia, you should actively communicate with the doctor to find the root cause of the hyperuricemia, and then adjust your life and diet. Medication adjustment to stabilize blood uric acid levels.