Cephalosporin + wine, go away? Doctor: In addition to cephalosporins, these 4 types of drugs are not suitable for drinking

Cephalosporin is paired with wine, just go! You must have heard of this in everyday life. It refers to patients who drink alcohol after taking cephalosporins, which may lead to sudden death of the drunk.

　　Many people think that this sentence is exaggerated. It is obvious that cephalosporin is the most common antibiotic drug. It can cure diseases and save people. How can it lead to death when combined with alcohol?

　　But in fact, this is not alarmist. In fact, when many drugs and alcohol collide together, they will have different degrees of adverse reactions, such as the reduction of drug efficacy is one of them.

　　However, the combination of cephalosporin and wine is not as simple as reducing the efficacy of the drug. It will produce a chemical reaction, which is clinically referred to as the disulfiram reaction.

　　Whether it is oral cephalosporins, or infusions, injections containing cephalosporins. This reaction occurs as long as the cephalosporin enters the human body after drinking alcohol.

　　The so-called disulfiram is essentially a drug that helps people get rid of alcohol addiction. When it is used in combination with ethanol, it will inhibit the liver's ability to produce acetaldehyde dehydrogenase . That is to say, after ethanol enters the body, it can be rapidly metabolized by the liver as acetaldehyde, but acetaldehyde cannot be completely metabolized immediately.

　　In this case, a large amount of acetaldehyde will build up in the body, and then a series of reactions like drunkenness will occur. For example, patients may experience chest tightness, shortness of breath, nausea and vomiting, dizziness, headache, etc. In severe cases, serious problems such as low blood pressure, cyanosis of the lips, difficulty breathing, anaphylactic shock, and death may even occur .

　　The reason for the different symptoms of patients is mainly related to the dose of medication and the amount of alcohol consumed. The more you drink, the more alcoholic beverages you drink, the stronger the reaction will be.

　　In addition to the drug cephalosporins, the following types of drugs are not suitable for taking after drinking alcohol:

　　1. Antipyretic and analgesic

　　The most important things to mention here are aspirin and paracetamol. When these drugs enter the body, they will originally stimulate the mucous membrane of the digestive tract, and even cause problems such as peptic ulcer and mucosal inflammation .

　　If you still drink a lot while taking such drugs, it will undoubtedly aggravate the damage to the digestive tract. If the patient already has ulcers, and taking drugs and drinking alcohol at the same time, it may cause gastrointestinal bleeding and gastric perforation;

2. Antihypertensive drugs

　　There are many different types of antihypertensive drugs on the market , their mechanism of action and half-life are different, but their essence is the same, that is, to control the increase of blood pressure in patients.

　　If the patient has high blood pressure and drinks alcohol after taking antihypertensive drugs, both ethanol and acetaldehyde will stimulate the blood vessels, resulting in further vasodilation and faster blood pressure circulation . The patient 's blood pressure will drop rapidly in a short period of time , and even severe hypotension, shock, heart damage, and cardiovascular and cerebrovascular diseases will occur ;

3. Hypoglycemic drugs

　　Whether it is oral hypoglycemic drugs or insulin injections, doctors will emphasize one point, that is, they should not drink alcohol during the medication. The reason for this is that although the pancreas is not an organ that metabolizes alcohol, alcohol can stimulate the pancreas, leading to a large secretion of insulin , which in turn increases the risk of hypoglycemia.

　　In addition, many alcoholic beverages are originally high-calorie types. If the calories exceed the standard, it is not conducive to blood sugar control , which may cause the problem of postprandial blood sugar rise;

4. Sedative drugs

　　Drugs such as phenobarbital and diazepam are essentially brain depressants . Drinking alcohol on the basis of taking these drugs will speed up the absorption of drugs by the human body, but the speed of metabolizing drugs will slow down, resulting in an increase in the concentration of drugs in the blood in a short period of time .

　　And alcohol, a substance, originally had the effect of inhibiting the central system. Under the dual stimulation of drugs and alcohol, the central system is severely inhibited, and problems such as coma, shock, respiratory failure , and even death of the patient may occur.

　　Finally, it should be emphasized that from the perspective of physical health, no matter what drugs you take in your daily life, it is necessary to avoid drinking alcohol in order to ensure that the drugs can work effectively.

　　In addition, even if there is no abnormality or disease in the body, everyone should have a correct understanding of the harm of alcohol, and quitting alcohol is the first step towards health.