'Cefcoid with wine, just leave when you say go'? Notice! Drugs that need to be banned are also these

Recently, all medium and high-risk areas across the country have been cleared, and the epidemic in China has been basically controlled.

A lot of people started dating, let's go to a bar!

When it comes to drinking, many people will have such common sense: avoid drinking when you are sick and taking medicine.

If you are taking medication during this time, be careful!

As the saying goes, "Cefs go with wine, eat and go", but some people don't take it seriously, and some people don't know the reason. In addition, besides cephalosporins, what other drugs need to be banned from alcohol? After reading the article, don't be fooled again!

Why can't cephalosporin be paired with wine?

Cephalosporins can affect alcohol metabolism, causing the accumulation of its metabolite acetaldehyde in the body, causing adverse reactions in digestion, respiration, circulation, and nervous system.

Mild symptoms: nausea, vomiting, diarrhea, dizziness, sweating, palpitations, etc.;

Severe symptoms: respiratory depression, myocardial infarction, heart failure, mental confusion, etc.;

These symptoms are collectively referred to as disulfiram-like reactions.

Disulfiram is a drug for alcohol withdrawal that has been approved for marketing in many countries. Once this drug is taken, even if you drink a small amount of alcohol, it will make your body feel uncomfortable, such as nausea and vomiting, and make you no longer want to be near alcohol, so it is also called disulfiram or disulfiram.

Therefore, a reaction that produces symptoms similar to those after taking disulfiram is called a disulfiram-like reaction.

These reactions produced by taking disulfiram are caused by the inhibition of acetaldehyde dehydrogenase in the body by disulfiram.

Acetaldehyde dehydrogenase can eliminate the acetaldehyde produced by the human body itself. When its activity is inhibited, it will cause the accumulation of acetaldehyde in the body, resulting in acetaldehyde poisoning, which is a disulfiram-like reaction. And alcohol is also converted into acetaldehyde in the body, and more acetaldehyde accumulation will aggravate the symptoms of acetaldehyde poisoning.

Many cephalosporins have a structure called "tetrazolium", which also inhibits acetaldehyde dehydrogenase, but it will not cause poisoning as long as it is not overdose.

However, if alcohol is ingested before the drug is metabolized to failure, it will lead to additional accumulation of acetaldehyde in the body, resulting in a disulfiram-like reaction, which is life-threatening.

Why are some people ok with cephalosporins?

Some people have tried cephalosporins with wine, and they have not had any adverse reactions. What is the explanation?

In fact, not all cephalosporins contain tetrazolium side chains, such as cefotaxime, cefapirin, cefadroxil, etc., and not all cephalosporins have disulfiram-like reactions in clinical trials.

However, for the sake of life safety, cephalosporins are not recommended to be taken with alcohol-containing things, including wine, boozy chocolate, Huoxiangzhengqi water, and alcohol-containing medicines.

And those people who "match cephalosporins with wine, nothing to do" probably happened to have a small amount and used cephalosporins without tetrazolium side chains. It just so happened that the body's metabolic vitality was good at that time...

In short, we'd better not take risks.

Notice! Do not drink alcohol before or after taking cephalosporins!

In what order and when the cephalosporins and alcohol should enter the human body, it only depends on when the cephalosporins and alcohol can be metabolized, that is, they cannot be allowed to coexist!

No matter what substance, the metabolic rate in the human body will vary from person to person, so it is most reliable to take a conservative value.

After ingesting alcohol in the human body, only about 10% can be excreted in its original form through breathing, urination, perspiration, etc., and the other 90% needs to be excreted from the body through a complex metabolic process. If liver function is normal and there is no excessive drinking, normal people will metabolize alcohol within 48 hours.

Whether cephalosporins are administered orally or by injection, they will be absorbed into the blood within two to three hours. As long as they are properly administered, they will be metabolized within a week.

Taking cephalosporin before drinking and taking cephalosporin after drinking have the same damage to the human body, and will produce disulfiram-like adverse reactions.

Therefore, for our health, the interval between drinking and taking cephalosporins should be at least one week.

What other drugs should not be taken before or after drinking alcohol?

As a type of carcinogen, alcohol is risky to drink when you are in good health, and it is even more inappropriate to drink it when you are taking medicine. So, what medicines should you not drink before and after taking them?

Antibiotics

Such as cephalosporins, metronidazole, etc. It can cause a disulfiram-like reaction, which is life-threatening.

sedative hypnotics

Such as stability, barbiturate and so on. Both alcohol and such drugs have a sedative and hypnotic effect. Excessive sedation not only damages the brain, but also lowers blood pressure, which can be dangerous.

Hypoglycemic agents

Such as insulin, metformin, etc. May cause hypoglycemia and, in the presence of poor liver function, ketoacidosis.

Antihypertensive drugs

Such as reserpine, nifedipine, etc. It can cause hypotension, or central nervous system depression, which can be life-threatening in severe cases.

Antidepressants

such as sertraline and fluoxetine. If antidepressants are used together with alcohol, it is not "how to relieve worries, only Dukang", but may be "toasting your worries and worrying more".

non-steroidal anti-inflammatory drugs

Such as aspirin, ibuprofen, etc. Since these drugs and alcohol can cause irritation to the digestive tract, they can cause stomach ulcers and other diseases when used together.

Remember?

It is not advisable to mix cephalosporins with wine

in addition

Antibiotics, sedative-hypnotics,

antihypertensive, hypoglycemic, antidepressant,

non-steroidal anti-inflammatory drugs

These six types of drugs should not be taken before or after drinking alcohol

Expert of this article: Wen Chaochao, Master student of School of Basic Medicine, Shanxi Medical University

Reviewer: Jin Rui, Deputy Chief Pharmacist of Beijing Shijitan Hospital Affiliated to Capital Medical University